Alligators, deer, fox squirrels, raptors and songbirds are among the wildlife found on the refuge. The meandering eight-mile wildlife drive is a comfortable and accessible way to view the variety of upland and wetland habitats and their associated wildlife. An accessible observation tower overlooks the Houston Bottoms and provides waterfowl viewing during winter. The Uplands viewing platform provides birding opportunities year-round with raptors frequenting the surrounding open fields during late fall and winter. Eufaula NWR is a designated site on the Georgia Southern Rivers Birding Trail and the Wiregrass Birding Trail in Alabama. The U.S. Important Bird Area Committee has prioritized the refuge as globally significant for birds of conservation concern due to the high number of wintering rusty blackbirds.