Pee Dee NWR is located on US Highway 52 North, six miles north of Wadesboro, NC

From Charlotte, NC:  Take US Hwy. 74 East approximately 50 miles to Wadesboro, NC.  Turn left on U.S. Hwy. 52 North, and proceed 6 miles.  The Refuge Office will be on your right.

From Albemarle, NC:  Take US Hwy. 52 South for 22 miles.  The Refuge Office will be on your left.

From Rockingham, NC:  Take US Hwy. 74 West approximately 19 miles to Wadesboro, NC.  Turn right on US Hwy. 52 North, and proceed 6 miles.  The Refuge Office will be on your right.