The refuge lies within two hours driving time from metropolitan Baltimore, Maryland; Washington, D.C.; Wilmington, Delaware; and Philadelphia, Pennsylvania, and 22 miles southeast of the State capital of Dover. 

From Route 1, take Route 16 east for 1.1 miles toward Broadkill Beach; turn left onto Turkle Pond Road and travel 1.6 miles to the refuge office, visitor center, and Friends Store at Prime Hook.