From I-95, take Exit 220 (Titusville, State Road 406 Exit). Drive east on SR406, also known as Garden Street. Continue east on Garden Street for 4 miles and travel over the Max Brewer Causeway Bridge. The Refuge begins at the east side of the causeway.

To reach the Visitor Information Center, continue 4 miles past the Refuge entrance (remain to your right at the fork in the road) and the Visitor Center entrance sign will be on your right.