From downtown Tishomingo:

Follow Highway 78 to the eastern edge of town. Turn south on Refuge Road, at the high school (watch for sign). Follow Refuge Road 2 miles to the refuge visitor center. 

From downtown Durant:

On US Highway 75/69 North, exit on Highway 78/48 (left). Continue on Hwy. 78/48 towards Kenefic, turn left on Highway 22 and at the Nida intersection turn slightly right towards Milburn, Hwy 78. Upon entering Tishomingo (watch for sign), turn left on Refuge Road and follow for 2 miles to the refuge visitor center.