Yazoo National Wildlife Refuge is located in the heart of Mississippi's Delta Region, 28 miles south of Greenville, MS, and 61 miles north of Vicksburg, Mississippi. From Greenville take Highway 1 south to the refuge sign. Turn east on Yazoo Refuge Road, and proceed to the Headquarters sign. From Vicksburg travel north on Highway 61. Turn west onto Highway 436 and proceed approximately 5.5 miles to the refuge sign at Beargarden Road. Turn right on Beargarden Road and follow the signs to Refuge Office.