Peperomia wheeleri, family Piperacea, is an evergreen, glabrous, erect herb which may reach one meter in height. The stems root only at the base and may be up to 1 cm in diameter. The opposite leaves are entire, fleshy, elliptic to elliptic-obovate, with 3 or 5 main veins ascending from the base. They may be 5 to 7 centimeters long and 2 to 3 centimeters wide with the base tapered to a 1 centimeter petiole. The lower side of the leaf is inconspicuously black punctate. Inflorescenses are spikes, 10 to 16 centimeters long and 5 millimeters in diameter, which are borne solitary and opposite the leaves or at the leaf axils. Flowers are minute, approximately 0.5 millimeter in diameter.